Communication Dans Un Congrès Année : 2025

896eP Relationship between education and tumor extension at diagnosis in colorectal cancer: Findings from the CONSTANCES cohort

Résumé

Background Few studies examined social inequalities in colorectal cancer (CRC) with regards to tumor characteristics. This study examines the association between educational level and tumor extension at diagnosis in the French population-based CONSTANCES cohort. Methods Tumor extension was assessed using International Classification of Diseases codes and/or treatments received within the first year after CRC diagnosis. Tumor extension was categorized as carcinoma in situ (stage 0) and malignant CRC, divided into advanced (stage IV) and non-advanced (stages I-III). Logistic regression models were adjusted for socio-demographics, health behaviors and health status at inclusion. Analyses were also stratified by age (<50; ≥50), as CRC screening in France begins at Results Among 745 CRC cases, 21.5% were carcinoma in situ, and 78.5% were malignant (24.8% advanced, 75.2% non-advanced). Most cases were aged ≥50, and 53% were low educated. Low-educated people were more at risk of CRC whatever its extension (814 vs. 460/100,000 persons-years in higher-educated people) but the highest relative risk of CRC in carcinoma in situ (3.37 vs.1.64 in malignant), and among CRC cases, they were more likely to present carcinoma in situ than their counterparts (odds ratio: 1.77, Conclusions Our findings suggest that further studies are needed to identify the mechanisms underlying these associations.

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Dates et versions

hal-05603508 , version 1 (27-04-2026)

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N. Hamieh, A. Martinez, E. Wiernik, M. Zins, P. Grosclaude, et al.. 896eP Relationship between education and tumor extension at diagnosis in colorectal cancer: Findings from the CONSTANCES cohort. ESMO Congress 2025, Oct 2025, Berlin, Germany. pp.S551, ⟨10.1016/j.annonc.2025.08.1466⟩. ⟨hal-05603508⟩
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