Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis - Université Toulouse III - Paul Sabatier - Toulouse INP Accéder directement au contenu
Article Dans Une Revue Journal of the International AIDS Society Année : 2022

Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis

Julie Jesson
Connectez-vous pour contacter l'auteur
Marie-Hélène Aké-Assi
  • Fonction : Auteur
Kunjal Patel
Ali Judd
Marissa Vicari
Linda‐gail Bekker
Martina Penazzato
Intira Jeannie Collins
Amy Slogrove
  • Fonction : Auteur
Kate Powis
Paige Williams
  • Fonction : Auteur
Mogomotsi Matshaba
  • Fonction : Auteur
Lineo Thahane
  • Fonction : Auteur
Phoebe Nyasulu
  • Fonction : Auteur
Bhekumusa Lukhele
  • Fonction : Auteur
Lumumba Mwita
  • Fonction : Auteur
Sebastian Wanless
  • Fonction : Auteur
Tessa Goetghebuer
  • Fonction : Auteur
Claire Thorne
  • Fonction : Auteur
Josiane Warszawski
  • Fonction : Auteur
Luisa Galli
  • Fonction : Auteur
Annemarie M C van Rossum
  • Fonction : Auteur
Carlo Giaquinto
  • Fonction : Auteur
Magdalena Marczynska
  • Fonction : Auteur
Laura Marques
  • Fonction : Auteur
Filipa Prata
  • Fonction : Auteur
Luminita Ene
  • Fonction : Auteur
Lyuba Okhonskaya
  • Fonction : Auteur
Marisa Navarro
  • Fonction : Auteur
Antoinette Frick
  • Fonction : Auteur
Lars Naver
  • Fonction : Auteur
Christian Kahlert
Elizabeth Chappell
Vanessa Rouzier
  • Fonction : Auteur
Adias Marcelin
  • Fonction : Auteur
Regina Succi
  • Fonction : Auteur
Annette H Sohn
Azar Kariminia
  • Fonction : Auteur
Andrew Edmonds
  • Fonction : Auteur
Patricia Lelo
  • Fonction : Auteur
Rita Lyamuya
  • Fonction : Auteur
Edith Apondi Ogalo
  • Fonction : Auteur
Francesca Akoth Odhiambo
Andreas D Haas
Carolyn Bolton
  • Fonction : Auteur
Josephine Muhairwe
Hannock Tweya
  • Fonction : Auteur
Mariam Sylla
  • Fonction : Auteur
Marceline d'Almeida
  • Fonction : Auteur
Lorna Renner
  • Fonction : Auteur
Mark J Abzug
  • Fonction : Auteur
James Oleske
  • Fonction : Auteur
Murli Purswani
  • Fonction : Auteur
Chloe Teasdale
  • Fonction : Auteur
Harriet Nuwagaba-Biribonwoha
Valériane Leroy
Nicky Maxwell
  • Fonction : Auteur

Résumé

Introduction Adolescents living with HIV are subject to multiple co‐morbidities, including growth retardation and immunodeficiency. We describe growth and CD4 evolution during adolescence using data from the Collaborative Initiative for Paediatric HIV Education and Research (CIPHER) global project. Methods Data were collected between 1994 and 2015 from 11 CIPHER networks worldwide. Adolescents with perinatally acquired HIV infection (APH) who initiated antiretroviral therapy (ART) before age 10 years, with at least one height or CD4 count measurement while aged 10–17 years, were included. Growth was measured using height‐for‐age Z‐scores (HAZ, stunting if <‐2 SD, WHO growth charts). Linear mixed‐effects models were used to study the evolution of each outcome between ages 10 and 17. For growth, sex‐specific models with fractional polynomials were used to model non‐linear relationships for age at ART initiation, HAZ at age 10 and time, defined as current age from 10 to 17 years of age. Results A total of 20,939 and 19,557 APH were included for the growth and CD4 analyses, respectively. Half were females, two‐thirds lived in East and Southern Africa, and median age at ART initiation ranged from <3 years in North America and Europe to >7 years in sub‐Saharan African regions. At age 10, stunting ranged from 6% in North America and Europe to 39% in the Asia‐Pacific; 19% overall had CD4 counts <500 cells/mm 3 . Across adolescence, higher HAZ was observed in females and among those in high‐income countries. APH with stunting at age 10 and those with late ART initiation (after age 5) had the largest HAZ gains during adolescence, but these gains were insufficient to catch‐up with non‐stunted, early ART‐treated adolescents. From age 10 to 16 years, mean CD4 counts declined from 768 to 607 cells/mm 3 . This decline was observed across all regions, in males and females. Conclusions Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood.
Fichier principal
Vignette du fichier
JESSON_2022.pdf (1.83 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Licence : CC BY - Paternité

Dates et versions

hal-04552847 , version 1 (19-04-2024)

Licence

Paternité

Identifiants

Citer

Julie Jesson, Siobhan Crichton, Matteo Quartagno, Marcel Yotebieng, Elaine J Abrams, et al.. Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis. Journal of the International AIDS Society, 2022, 25 (3), pp.e25871. ⟨10.1002/jia2.25871⟩. ⟨hal-04552847⟩
0 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More