Where the building industry already uses drones for outside inspection and digitization activities, this paper proposes the use of multi-usages drones able to perform various services inside buildings, ranging from inspection, digitization, monitoring health and evaluation of technical performances of the building. Related to four different operational environments (use-cases), such multi-usages drones need to be able to be adapted for their specific use, raising specific design challenges that increase the complexity of the system. A Model-Based Systems Engineering approach is proposed and applied to address this complexity, so to develop a customizable architecture. First results of this work are presented in this paper, part of the ‘Indoor Multi-Usages Drone Acquisition’ (IMUDA) project.