Lipid Interactions Between Flaviviruses and Mosquito Vectors - Université Toulouse III - Paul Sabatier - Toulouse INP Accéder directement au contenu
Article Dans Une Revue Frontiers in Physiology Année : 2021

Lipid Interactions Between Flaviviruses and Mosquito Vectors

Résumé

Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations. In absence of therapeutics and effective vaccines against each flaviviruses, targeting viral metabolic requirements in mosquitoes may hold the key to new intervention strategies. Development of metabolomics in the last decade opened a new field of research: mosquito metabolomics. It is now clear that flaviviruses rely on mosquito lipids, especially phospholipids, for their cellular cycle and propagation. Here, we review the biosyntheses of, biochemical properties of and flaviviral interactions with mosquito phospholipids. Phospholipids are structural lipids with a polar headgroup and apolar acyl chains, enabling the formation of lipid bilayer that form plasma- and endomembranes. Phospholipids are mostly synthesized through the de novo pathway and remodeling cycle. Variations in headgroup and acyl chains influence phospholipid physicochemical properties and consequently the membrane behavior. Flaviviruses interact with cellular membranes at every step of their cellular cycle. Recent evidence demonstrates that flaviviruses reconfigure the phospholipidome in mosquitoes by regulating phospholipid syntheses to increase virus multiplication. Identifying the phospholipids involved and understanding how flaviviruses regulate these in mosquitoes is required to design new interventions.
Fichier principal
Vignette du fichier
Vial_2021.pdf (4.57 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03542654 , version 1 (25-01-2022)

Identifiants

Citer

Thomas Vial, Guillaume Marti, Dorothée Missé, Julien Pompon. Lipid Interactions Between Flaviviruses and Mosquito Vectors. Frontiers in Physiology, 2021, 12, pp.763195. ⟨10.3389/fphys.2021.763195⟩. ⟨hal-03542654⟩
27 Consultations
35 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More