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A harmonically trapped active Brownian particle exhibits two types of positional distributions—one has a single peak and the other has a single well—that signify steady-state dynamics with low and high activity, respectively. Adding inertia to the translational motion preserves this strict classification of either single-peak or single-well densities but shifts the dividing boundary between the states in the parameter space. We characterize this shift for the dynamics in one spatial dimension using the static Fokker-Planck equation for the full joint distribution of the state space. We derive local results analytically with a perturbation method for a small rotational velocity and then extend them globally with a numerical approach.
T-cell cytotoxic function relies on the cooperation between the highly specific but poorly adhesive T-cell receptor (TCR) and the integrin LFA-1. How LFA-1-mediated adhesion may scale with TCR stimulation strength is ill-defined. Here, we show that LFA-1 conformation activation scales with TCR stimulation to calibrate human T-cell cytotoxicity. Super-resolution microscopy analysis reveals that >1000 LFA-1 nanoclusters provide a discretized platform at the immunological synapse to translate TCR engagement and density of the LFA-1 ligand ICAM-1 into graded adhesion. Indeed, the number of high-affinity conformation LFA-1 nanoclusters increases as a function of TCR triggering strength. Blockade of LFA-1 conformational activation impairs adhesion to target cells and killing. However, it occurs at a lower TCR stimulation threshold than lytic granule exocytosis implying that it licenses, rather than directly controls, the killing decision. We conclude that the organization of LFA-1 into nanoclusters provides a calibrated system to adjust T-cell killing to the antigen stimulation strength.
Modern computing has enhanced our understanding of how social interactions shape collective behaviour in animal societies. Although analytical models dominate in studying collective behaviour, this study introduces a deep learning model to assess social interactions in the fish species Hemigrammus rhodostomus . We compare the results of our deep learning approach with experiments and with the results of a state-of-the-art analytical model. To that end, we propose a systematic methodology to assess the faithfulness of a collective motion model, exploiting a set of stringent individual and collective spatio-temporal observables. We demonstrate that machine learning (ML) models of social interactions can directly compete with their analytical counterparts in reproducing subtle experimental observables. Moreover, this work emphasizes the need for consistent validation across different timescales, and identifies key design aspects that enable our deep learning approach to capture both short- and long-term dynamics. We also show that our approach can be extended to larger groups without any retraining, and to other fish species, while retaining the same architecture of the deep learning network. Finally, we discuss the added value of ML in the context of the study of collective motion in animal groups and its potential as a complementary approach to analytical models.
We complete the kinetic theory of inhomogeneous systems with long-range interactions initiated in previous works. We use a simpler and more physical formalism. We consider a system of particles submitted to a small external stochastic perturbation and determine the response of the system to the perturbation. We derive the diffusion tensor and the friction by polarization of a test particle. We introduce a general Fokker–Planck equation involving a diffusion term and a friction term. When the friction by polarization can be neglected, we obtain a secular dressed diffusion equation sourced by the external noise. When the external perturbation is created by a discrete collection of N field particles, we obtain the inhomogeneous Lenard–Balescu kinetic equation reducing to the inhomogeneous Landau kinetic equation when collective effects are neglected. We consider a multi-species system of particles. When the field particles are at statistical equilibrium (thermal bath), we establish the proper expression of the fluctuation–dissipation theorem for systems with long-range interactions relating the power spectrum of the fluctuations to the response function of the system. In that case, the friction and diffusion coefficients satisfy the Einstein relation and the Fokker–Planck equation reduces to the inhomogeneous Kramers equation. We also consider a gas of Brownian particles with long-range interactions described by N coupled stochastic Langevin equations and determine its mean and mesoscopic evolution. We discuss the notion of stochastic kinetic equations and the role of fluctuations possibly triggering random transitions from one equilibrium state to the other. Our presentation parallels the one given for the kinetic theory of two-dimensional point vortices in a previous paper (Chavanis in Eur Phys J Plus 138:136, 2023).
Nanofluidics has a very promising future owing to its numerous applications in many domains. It remains, however, very difficult to understand the basic physico-chemical principles that control the behavior of solvents confined in nanometric channels. Here, water and ion transport in carbon nanotubes is investigated using classical force field molecular dynamics simulations. By combining one single walled carbon nanotube (uniformly charged or not) with two perforated graphene sheets, we mimic single nanopore devices similar to experimental ones. The graphitic edges delimit two reservoirs of water and ions in the simulation cell from which a voltage is imposed through the application of an external electric field. By analyzing the evolution of the electrolyte conductivity, the role of the carbon nanotube geometric parameters (radius and chirality) and of the functionalization of the carbon nanotube entrances with OH or COO− groups is investigated for different concentrations of group functions.
Sujets
Collective behavior
Wave function
Mass density
Diffusion
General relativity
9880-k
Chemotaxis
Dissipation
Nanofiltration
Quantum mechanics
Entropy
Structure
Dark matter halo
9530Sf
Current fluctuations
Numerical calculations
Hydrodynamics
Turbulence
Dark energy
Kinetic theory
Field theory scalar complex
9862Gq
TASEP
Gravitational collapse
Brownian motion
Critical phenomena
Einstein
Collective behaviour
Scalar field
Collisionless stellar-systems
Distributed Control
Euler-Maclaurin
Feedback
Fermi gas
Atmosphere
Random walker
Statistical mechanics
Energy internal
Bose–Einstein condensates
Formation
Cosmological constant
Dark matter fuzzy
Pressure
Thermodynamics
Denaturation
Quantum chromodynamics axion
Effondrement gravitationnel
Dark matter condensation
Physique statistique
Evaporation
Cosmology
Energy density
Bethe ansatz
Smoluchowski equation
Competition
Condensation Bose-Einstein
Computational modelling
Dark matter
Collapse
9535+d
Cosmological model
Phase separation
Halo
Dark matter density
Galaxy
Computational modeling
Collective motion
Expansion acceleration
DNA
Asymptotic behavior
Mouvement brownien
Equation of state
Bose-Einstein
Scattering length
Transition vitreuse
Dark matter theory
Gravitation
Fermion dark matter
Marcheur aléatoire
Field theory scalar
Nonrelativistic
Fokker-Planck
Black hole
Gas Chaplygin
Catastrophe theory
Rotation
Stability
Gravitation collapse
Gravitation self-force
Fermions
Chemotaxie
Effect relativistic
Smoluchowski-Poisson
Axion star
Fermion
Density
Axion
9536+x
Keller-Segel
Energy high