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Article Dans Une Revue Aging and disease Année : 2024

G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease

Résumé

that G9a directly bound GMFB and catalyzed the methylation at lysine (K) 20 and K25 in vitro. Furthermore, we found that the neurodegenerative role of G9a as a GMFB suppressor would mainly rely on methylation of the K25 position of GMFB, and thus G9a pharmacological inhibition removes this methylation promoting neuroprotective effects. Then, our findings confirm an undescribed mechanism by which G9a inhibition acts at two levels, increasing GMFB and regulating its function to promote neuroprotective effects in age-related cognitive decline.
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Dates et versions

hal-04481784 , version 1 (28-02-2024)

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Aina Bellver-Sanchis, Qizhi Geng, Gemma Navarro, Pedro A Ávila-López, Júlia Companys-Alemany, et al.. G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease. Aging and disease, 2024, 15, pp.311-337. ⟨10.14336/ad.2023.0424-2⟩. ⟨hal-04481784⟩
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