Article Dans Une Revue International Journal of Molecular Sciences Année : 2021

Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications

Résumé

Bone is a multi-skilled tissue, protecting major organs, regulating calcium phosphate balance and producing hormones. Its development during childhood determines height and stature as well as resistance against fracture in advanced age. Estrogens are key regulators of bone turnover in both females and males. These hormones play a major role in longitudinal and width growth throughout puberty as well as in the regulation of bone turnover. In women, estrogen deficiency is one of the major causes of postmenopausal osteoporosis. In this review, we will summarize the main clinical and experimental studies reporting the effects of estrogens not only in females but also in males, during different life stages. Effects of estrogens on bone involve either Estrogen Receptor (ER)α or ERβ depending on the type of bone (femur, vertebrae, tibia, mandible), the compartment (trabecular or cortical), cell types involved (osteoclasts, osteoblasts and osteocytes) and sex. Finally, we will discuss new ongoing strategies to increase the benefit/risk ratio of the hormonal treatment of menopause.
Fichier principal
Vignette du fichier
Noirrit-Esclassan_2021.pdf (969.47 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte
Licence

Dates et versions

hal-04835626 , version 1 (13-12-2024)

Licence

Identifiants

Citer

Emmanuelle Noirrit-Esclassan, Marie-Cecile Valera, Florence Trémollieres, Jean-François Arnal, Françoise Lenfant, et al.. Critical Role of Estrogens on Bone Homeostasis in Both Male and Female: From Physiology to Medical Implications. International Journal of Molecular Sciences, 2021, 22 (4), pp.1568. ⟨10.3390/ijms22041568⟩. ⟨hal-04835626⟩
12 Consultations
11 Téléchargements

Altmetric

Partager

More