Fatal mucormycosis and aspergillosis coinfection associated with haemophagocytic lymphohistiocytosis: A case report and literature review - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Journal of Medical Mycology = Journal de Mycologie Médicale Année : 2022

Fatal mucormycosis and aspergillosis coinfection associated with haemophagocytic lymphohistiocytosis: A case report and literature review

Résumé

Invasive mould infections are life-threatening and mainly occur in immunocompromised patients. Whereas aspergillosis is described during haemophagocytic lymphohistiocytosis (HLH), only a few cases of concomitant mucormycosis with HLH have been reported. Here, we present an uncommon coinfection of mucormycosis and aspergillosis associated with HLH probably due to a varicella zoster virus (VZV) viraemia which was unresponsive to triple antifungal therapy (liposomal amphotericin B combined with isavuconazole and caspofungin). A review of the cases of mucormycosis with HLH showed that this uncommon association was always lethal and underscored the relevance of screening for mould infections in patients with HLH.

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hal-04726175 , version 1 (08-10-2024)

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Dorian Loubet, Benjamine Sarton, Lucie Lelièvre, Gaspard Grouteau, Xavier Iriart, et al.. Fatal mucormycosis and aspergillosis coinfection associated with haemophagocytic lymphohistiocytosis: A case report and literature review. Journal of Medical Mycology = Journal de Mycologie Médicale, 2022, 33 (1), pp.101325. ⟨10.1016/j.mycmed.2022.101325⟩. ⟨hal-04726175⟩
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