EAACI Molecular Allergology User's Guide 2.0 - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Pediatric Allergy and Immunology Année : 2023

EAACI Molecular Allergology User's Guide 2.0

Stephanie Dramburg (1) , Christiane Hilger (2) , Alexandra Santos (3, 4) , Leticia de las Vecillas (5) , Rob Aalberse (6) , Nathalie Acevedo (7) , Lorenz Aglas (8) , Friedrich Altmann (9) , Karla Arruda (10) , Riccardo Asero (11) , Barbara Ballmer-Weber (12) , Domingo Barber (13, 14, 15) , Kirsten Beyer (1) , Tilo Biedermann (16) , Maria Beatrice Bilo (17, 18) , Simon Blank (16, 19) , Philipp P. Bosshard (20) , Heimo Breiteneder (21) , Helen Brough (3, 4) , Merima Bublin (21) , Dianne Campbell (22, 23) , Luis Caraballo (7) , Jean Christoph Caubet (24) , Giorgio Celi (25) , Martin Chapman (26) , Maksymilian Chruszcz (27) , Adnan Custovic (28) , Rebecca Czolk (2, 29) , Janet Davies (30, 31) , Nikolaos Douladiris (32) , Bernadette Eberlein (16) , Motohiro Ebisawa (33) , Anna Ehlers (34) , Philippe Eigenmann (24) , Gabriele Gadermaier (8) , Mattia Giovannini (35) , Francisca Gomez (36, 14) , Rebecca Grohman (37) , Carole Guillet (20, 38) , Christine Hafner (39) , Robert G. Hamilton (40) , Michael Hauser (8) , Thomas Hawranek (41) , Hans Jürgen Hoffmann (42, 43) , Thomas Holzhauser (44) , Tomona Iizuka (45) , Alain Jacquet (46) , Thilo Jakob (47) , Bente Janssen-Weets (2, 48) , Uta Jappe (49, 50, 51) , Marek Jutel (52) , Tanja Kalic (21, 39) , Sandip Kamath (53) , Sabine Kespohl (54) , Jörg Kleine-Tebbe (55) , Edward Knol (34) , André Knulst (34) , Jon Konradsen (56, 57) , Peter Korošec (58) , Annette Kuehn (2) , Gideon Lack (3, 4) , Thuy‐my Le (34) , Andreas Lopata (53) , Olga Luengo (14, 15, 59, 60) , Mika Mäkelä (61, 62) , Alessandro Maria Marra (63) , Clare Mills (64) , Martine Morisset (65) , Antonella Muraro (66) , Anna Nowak-Wegrzyn (67, 68) , Roni Nugraha (53, 69) , Markus Ollert (2, 48) , Kati Palosuo (61, 62) , Elide Anna Pastorello (70) , Sarita Ulhas Patil (71, 72) , Thomas Platts-Mills (73) , Anna Pomés (26) , Pascal Poncet (74, 75) , Ekaterina Potapova (1) , Lars Poulsen (76) , Christian Radauer (21) , Suzana Radulovic (3, 4) , Monika Raulf (54) , Pierre Rougé (77) , Joaquin Sastre (78) , Sakura Sato (32) , Enrico Scala (79) , Johannes Schmid (43) , Peter Schmid-Grendelmeier (20, 80) , Denise Schrama (81) , Hélène Sénéchal (75) , Claudia Traidl-Hoffmann (80, 82) , Marcela Valverde-Monge (83) , Marianne van Hage (56, 57) , Ronald van Ree (6) , Kitty Verhoeckx (34) , Stefan Vieths (44) , Magnus Wickman (56) , Josefina Zakzuk (7) , Paolo M. Matricardi (1) , Karin Hoffmann-Sommergruber (21)
1 Charité - UniversitätsMedizin = Berlin University Medicine
2 LIH - Luxembourg Institute of Health
3 King‘s College London
4 Guy's and St Thomas' Hospital [London]
5 La Paz University Hospital
6 UvA - University of Amsterdam [Amsterdam] = Universiteit van Amsterdam
7 University of Cartagena
8 PLUS - Paris-Lodron-Universität Salzburg = Paris-Lodron-University of Salzburg
9 BOKU - Universität für Bodenkultur Wien = University of Natural Resources and Life Sciences [Vienne, Autriche]
10 USP - Universidade de São Paulo = University of São Paulo
11 CSC - Clinica San Carlo [Milan, Italy]
12 Brustzentrum Kantonsspital St. Gallen
13 Universidad San Pablo CEU
14 RETICS ARADyAL - Red Temática de Investigación Cooperativa en Salud : Asma, Reacciones Adversas a Fármacos y Alérgicas [Spain]
15 REI - Red de enfermedades inflamatorias [Spain]
16 TUM - Technische Universität Munchen - Technical University Munich - Université Technique de Munich
17 UNIVPM - Polytechnic University of Marche [Ancona, Italy] / Università Politecnica delle Marche [Ancona, Italia]
18 AOR - University Hospital Ospedali Riuniti [Ancona, Italy]
19 HMGU - Helmholtz Zentrum München = German Research Center for Environmental Health
20 University hospital of Zurich [Zurich]
21 Medizinische Universität Wien = Medical University of Vienna
22 Sydney Children's hospital
23 The University of Sydney
24 HUG - Hôpitaux universitaires de Genève = University Hospitals of Geneva
25 ASST - Azienda Socio Sanitaria Territoriale di Mantova [Mantova, Italy]
26 InBio [Charlottesville, VA, USA]
27 University of South Carolina [Columbia]
28 Imperial College London
29 uni.lu - Université du Luxembourg = University of Luxembourg = Universität Luxemburg
30 QUT - Queensland University of Technology [Brisbane]
31 Metro North HHS - Metro North Hospital and Health Service [Herston, Australia]
32 NKUA - National and Kapodistrian University of Athens
33 Sagamihara National Hospital [Kanagawa, Japan]
34 Universiteit Utrecht / Utrecht University [Utrecht]
35 AOU Meyer - Azienda Ospedaliero Universitaria Meyer [Firenze] = Meyer Children's University Hospital [Florence]
36 Hospital Regional Universitario de Málaga = Regional University Hospital of Malaga [Spain]
37 NYU Langone Health [New York]
38 UZH - Universität Zürich [Zürich] = University of Zurich
39 Karl Landsteiner University of Health Sciences - Karl Landsteiner Privatuniversität für Gesundheitswissenschaften [Krems an der Donau, Austria]
40 Johns Hopkins University School of Medicine [Baltimore]
41 PMU - Paracelsus Medizinische Privatuniversität = Paracelsus Medical University
42 Aarhus University [Aarhus]
43 Aarhus University Hospital
44 EPI - Paul-Ehrlich-Institute - Federal Institute for Vaccines and Biomedicines
45 Hokkaido University [Sapporo, Japan]
46 Chulalongkorn University [Bangkok]
47 JLU - Justus-Liebig-Universität Gießen = Justus Liebig University
48 SDU - University of Southern Denmark
49 Forschungszentrum Borstel, Leibniz Lungenzentrum - Research Center Borstel, Leibniz Lung Center [Sülfeld, Germany]
50 German Center for Lung Research
51 Universität zu Lübeck = University of Lübeck [Lübeck]
52 Wrocław Medical University
53 JCU - James Cook University
54 RUB - Ruhr University Bochum = Ruhr-Universität Bochum
55 AAZW - Allergie- und Asthma-Zentrum Westend = Allergy and Asthma Center Westend [Berlin, Germany]
56 Karolinska Institutet [Stockholm]
57 Karolinska University Hospital [Stockholm]
58 University Clinic of Respiratory and Allergic Diseases Golnik [Golnik, Slovenia]
59 Vall d'Hebron University Hospital [Barcelona]
60 UAB - Universitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona
61 HUS - Helsinki University Hospital [Finland]
62 Helsingin yliopisto = Helsingfors universitet = University of Helsinki
63 ASST - Azienda Socio Sanitaria Territoriale Rhodense [Milano, Italy]
64 University of Manchester [Manchester]
65 CHU Angers - Centre Hospitalier Universitaire d'Angers
66 AOUP - Azienda Ospedale Università di Padova = Hospital-University of Padua
67 NYU Grossman School of Medicine - New York University School of Medicine
68 University of Warmia and Mazury [Olsztyn]
69 Bogor Agricultural University - IPB (INDONESIA)
70 Casa di cura Ambrosiana = Ambrosiana Nursing Home [Milano, Italy]
71 HMS - Harvard Medical School [Boston]
72 Massachusetts General Hospital [Boston]
73 University of Virginia
74 Département d'Immunologie - Department of Immunology
75 CHU Trousseau [APHP]
76 Copenhagen University Hospital
77 PHARMA-DEV - Pharmacochimie et Biologie pour le Développement
78 UAM - Universidad Autónoma de Madrid
79 IRCCS IDI - Istituto di Ricovero e Cura a Carattere Scientifico Istituto Dermopatico dell’Immacolata Fondazione Monti [Roma, Italy]
80 Christine Kuhne-Center for Allergy Research and Education (CK-CARE), Davos, Switzerland
81 UAlg - Universidade do Algarve
82 UNIA - Universität Augsburg [Deutschland] = University of Augsburg [Germany] = Université d'Augsburg [Allemagne]
83 Hospital Universitario Fundación Jiménez Díaz [Madrid, Spain]
Christiane Hilger
Leticia de las Vecillas
Nathalie Acevedo
Riccardo Asero
Luis Caraballo
Martin Chapman
Adnan Custovic
Tomona Iizuka
Alain Jacquet
Sandip Kamath
Annette Kuehn
Andreas Lopata
Clare Mills
Thomas Platts-Mills
Anna Pomés
Lars Poulsen
Joaquin Sastre
Johannes Schmid
Denise Schrama
Hélène Sénéchal
Magnus Wickman
Josefina Zakzuk

Résumé

Since the discovery of immunoglobulin E (IgE) as a mediator of allergic diseases in 1967, our knowledge about the immunological mechanisms of IgE‐mediated allergies has remarkably increased. In addition to understanding the immune response and clinical symptoms, allergy diagnosis and management depend strongly on the precise identification of the elicitors of the IgE‐mediated allergic reaction. In the past four decades, innovations in bioscience and technology have facilitated the identification and production of well‐defined, highly pure molecules for component‐resolved diagnosis (CRD), allowing a personalized diagnosis and management of the allergic disease for individual patients. The first edition of the “EAACI Molecular Allergology User's Guide” (MAUG) in 2016 rapidly became a key reference for clinicians, scientists, and interested readers with a background in allergology, immunology, biology, and medicine. Nevertheless, the field of molecular allergology is moving fast, and after 6 years, a new EAACI Taskforce was established to provide an updated document. The Molecular Allergology User's Guide 2.0 summarizes state‐of‐the‐art information on allergen molecules, their clinical relevance, and their application in diagnostic algorithms for clinical practice. It is designed for both, clinicians and scientists, guiding health care professionals through the overwhelming list of different allergen molecules available for testing. Further, it provides diagnostic algorithms on the clinical relevance of allergenic molecules and gives an overview of their biology, the basic mechanisms of test formats, and the application of tests to measure allergen exposure.
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Dates et versions

hal-04615555 , version 1 (18-06-2024)

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Stephanie Dramburg, Christiane Hilger, Alexandra Santos, Leticia de las Vecillas, Rob Aalberse, et al.. EAACI Molecular Allergology User's Guide 2.0. Pediatric Allergy and Immunology, 2023, 34 (S28), pp.e13854. ⟨10.1111/pai.13854⟩. ⟨hal-04615555⟩
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