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Article Dans Une Revue Molecular and Cellular Endocrinology Année : 2021

The therapeutic potentials of apelin in obesity-associated diseases

Résumé

Apelin, a peptide with several active isoforms ranging from 36 to 12 amino acids and its receptor APJ, a G-protein-coupled receptor, are widely distributed. However, apelin has emerged as an adipokine more than fifteen years ago, integrating the field of inter-organs interactions. The apelin/APJ system plays important roles in several physiological functions both in rodent and humans such as fluid homeostasis, cardiovascular physiology, angiogenesis, energy metabolism. Thus the apelin/APJ system has generated great interest as a potential therapeutic target in different pathologies. The present review will consider the effects of apelin in metabolic diseases such as obesity and diabetes with a focus on diabetic cardiomyopathy among the complications associated with diabetes and APJ agonists or antagonists of interest in these diseases.
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hal-04569524 , version 1 (22-07-2024)

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I. Castan-Laurell, C. Dray, P. Valet. The therapeutic potentials of apelin in obesity-associated diseases. Molecular and Cellular Endocrinology, 2021, 529, pp.111278. ⟨10.1016/j.mce.2021.111278⟩. ⟨hal-04569524⟩
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