Description of a European memory clinic cohort undergoing amyloid‐PET: The AMYPAD Diagnostic and Patient Management Study - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Alzheimer's & Dementia : the Journal of the Alzheimer's Association Année : 2018

Description of a European memory clinic cohort undergoing amyloid‐PET: The AMYPAD Diagnostic and Patient Management Study

Pierre Payoux
Laure Saint‐Aubert
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Zuzana Walker
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Ho‐yun Lee
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Lean Lee
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Jean‐françois Demonet
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Sonia Plaza Wuthrich
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Rossella Gismondi
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Gill Farrar
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Andrew W Stephens
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Résumé

Introduction: AMYPAD Diagnostic and Patient Management Study (DPMS) aims to investigate the clinical utility and cost-effectiveness of amyloid-PET in Europe. Here we present participants' baseline features and discuss the representativeness of the cohort. Methods: Participants with subjective cognitive decline plus (SCD+), mild cognitive impairment (MCI), or dementia were recruited in eight European memory clinics from April 16, 2018, to October 30, 2020, and randomized into three arms: ARM1, early amyloid-PET; ARM2, late amyloid-PET; and ARM3, free-choice. Results: A total of 840 participants (244 SCD+, 341 MCI, and 255 dementia) were enrolled. Sociodemographic/clinical features did not differ significantly among recruiting memory clinics or with previously reported cohorts. The randomization assigned 35% of participants to ARM1, 32% to ARM2, and 33% to ARM3; cognitive stages were distributed equally across the arms. Discussion: The features of AMYPAD-DPMS participants are as expected for a memory clinic population. This ensures the generalizability of future study results.
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hal-04403120 , version 1 (18-01-2024)

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Daniele Altomare, Lyduine Collij, Camilla Caprioglio, Philip Scheltens, Bart N M van Berckel, et al.. Description of a European memory clinic cohort undergoing amyloid‐PET: The AMYPAD Diagnostic and Patient Management Study. Alzheimer's & Dementia : the Journal of the Alzheimer's Association, 2018, 19 (3), pp.844 - 856. ⟨10.1002/alz.12696⟩. ⟨hal-04403120⟩
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