Alternative Ligands at Melatonin Receptors - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Methods in Molecular Biology Année : 2022

Alternative Ligands at Melatonin Receptors

Résumé

Melatonin (N-acetyl-5-methoxytryptamine) is a neurohormone that possesses a wide range of biological effects. Most of the main recognized effects of this hormone in mammals are due to its interaction with two G protein-coupled receptors, MT1 and MT2. Ligand-binding studies have been based on the use of its radioligand analog, 2[125I]-iodomelatonin, a super agonist discovered in the early 1990s. This compound has been used in most of the binding studies reported in the literature. Nevertheless, more recently other possibilities arose. This chapter is a brief summary of those alternative radioligands and of their benefits one can find in using them.
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Dates et versions

hal-04037116 , version 1 (20-03-2023)

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Citer

Céline Legros, Said Yous, Jean Boutin. Alternative Ligands at Melatonin Receptors. Methods in Molecular Biology, 2022, Methods in Molecular Biology, 2550, pp.151-162. ⟨10.1007/978-1-0716-2593-4_19⟩. ⟨hal-04037116⟩
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