The RNA regulatory programs that govern lymphocyte development and function - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Wiley Interdisciplinary Reviews-RNA Année : 2022

The RNA regulatory programs that govern lymphocyte development and function

Résumé

Lymphocytes require of constant and dynamic changes in their transcriptome for timely activation and production of effector molecules to combat external pathogens. Synthesis and translation of messenger (m)RNAs into these effector proteins is controlled both quantitatively and qualitatively by RNA binding proteins (RBPs). RBP-dependent regulation of RNA editing, subcellular location, stability, and translation shapes immune cell development and immunity. Extensive evidences have now been gathered from few model RBPs, HuR, PTBP1, ZFP36, and Roquin. However, recently developed methodologies for global characterization of protein:RNA interactions suggest the existence of complex RNA regulatory networks in which RBPs co-ordinately regulate the fate of sets of RNAs controlling cellular pathways and functions. In turn, RNA can also act as scaffolding of functionally related proteins modulating their activation and function. Here we review current knowledge about how RBP-dependent regulation of RNA shapes our immune system and discuss about the existence of a hidden immune cell epitranscriptome.
Fichier non déposé

Dates et versions

hal-03778809 , version 1 (16-09-2022)

Identifiants

Citer

Manuel Diaz-Muñoz, Ines Osma-Garcia. The RNA regulatory programs that govern lymphocyte development and function. Wiley Interdisciplinary Reviews-RNA, 2022, 13 (1), pp.e1683. ⟨10.1002/wrna.1683⟩. ⟨hal-03778809⟩
24 Consultations
0 Téléchargements

Altmetric

Partager

More