CD4+ T cells that help B cells – a proposal for uniform nomenclature - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Trends in Immunology Année : 2021

CD4+ T cells that help B cells – a proposal for uniform nomenclature

Résumé

T follicular helper (Tfh) cells cognately guide differentiation of antigen-primed B cells in secondary lymphoid tissues. 'Tfh-like' populations not expressing the canonical Tfh cell transcription factor BCL6 have also been described, which can aid particular aspects of B cell differentiation. Tfh and Tfh-like cells are essential for protective and pathological humoral immunity. These CD4+ T cells that help B cells are polarized to produce diverse combinations of cytokines and chemokine receptors and can be grouped into distinct subsets that promote antibodies of different isotype, affinity, and duration, according to the nature of immune challenge. However, unified nomenclature to describe the distinct functional Tfh and Tfh-like cells does not exist. While explicitly acknowledging cellular plasticity, we propose categorizing these cell states into three groups based on phenotype and function, paired with their anatomical site of action.

Dates et versions

hal-03775861 , version 1 (13-09-2022)

Identifiants

Citer

Stephanie Eisenbarth, Dirk Baumjohann, Joe Craft, Nicolas Fazilleau, Cindy Ma, et al.. CD4+ T cells that help B cells – a proposal for uniform nomenclature. Trends in Immunology, 2021, 42 (8), pp.658-669. ⟨10.1016/j.it.2021.06.003⟩. ⟨hal-03775861⟩
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