Kinetics of serum hepcidin and interleukin-6 levels following COVID-19 infection in hemodialysis patients
Résumé
Patients with chronic kidney disease (CKD), particularly those undergoing hemodialysis (HD), are at high risk of a severe form of coronavirus disease 2019 (COVID-19). Recently we showed that an elevated neutrophil: lymphocyte ratio at day 7 of COVID-19 predicted outcome in adult HD patients. Elevated serum C reactive protein (CRP) and ferritin were also hallmarks of the disease, confirming that, similar to all COVID-19 patients, hyperinflammation and iron disorder are also present in HD patients. Here we additionally explored hepcidin, the master regulator of iron homeostasis that has rarely been measured in COVID-19 and interleukin-6 (IL-6), the cytokine that stimulates hepcidin in inflammatory conditions.
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