Dehydrohalogenation of halobenzenes and C(sp(3))-X (X = F, OPh) bond activation by a molecular calcium hydride - Université Toulouse III - Paul Sabatier - Toulouse INP Accéder directement au contenu
Article Dans Une Revue Tetrahedron Année : 2021

Dehydrohalogenation of halobenzenes and C(sp(3))-X (X = F, OPh) bond activation by a molecular calcium hydride

Résumé

The molecular calcium hydride, [(BDI)CaF](2) (BDI = HC{(Me)CN-2,6-i-Pr2C6H3}(2)), effects the slow hydrodehalogenation of C6H5X (X = I, Br) to provide benzene and the respective dimeric calcium halides, [(BDI)CaX](2). Although a similar reaction with fluorobenzene was non-discriminating, the analogous hydrogenation of chlorobenzene was observed, albeit this process yields the calcium hydride-chloride as the alkaline earth-containing product. Assessment of the bromide- and chloride-based processes by density functional theory (DFT) calculations, imply that the reactions take place with the retention of the dimeric calcium structures throughout. Both systems invoke an S N Ar-type displacement of the halide, via barriers (in the range 32-34 kcal mol(-1) for C6H5Br and 31.1-32.9 kcal mol(-1) for C6H5Cl), which vary only marginally during the transformation of the initial hydride and halide-hydride intermediates. The isolation of the calcium hydride-chloride is ascribed, therefore, to its more rapid crystallisation and depletion from solution. Also reported is the reactivity of [(BDI)CaH](2) with alpha,alpha,alpha-trifluorotoluene and anisole, which yield the corresponding dicalcium hydride-fluoride and phenoxide derivatives, respectively, rather than the products of directed ortho metalation. (C) 2021 Elsevier Ltd. All rights reserved.
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hal-03717244 , version 1 (22-03-2023)

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Paternité - Pas d'utilisation commerciale

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Andrew S. S. Wilson, Michael S. Hill, Mary F. Mahon, Chiara Dinoi, Laurent Maron. Dehydrohalogenation of halobenzenes and C(sp(3))-X (X = F, OPh) bond activation by a molecular calcium hydride. Tetrahedron, 2021, 82, ⟨10.1016/j.tet.2021.131931⟩. ⟨hal-03717244⟩
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