New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Molecules Année : 2013

New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities

Résumé

Malaria and leishmaniasis are two of the World’s most important tropical parasitic diseases. Continuing with our efforts to identify new compounds active against malaria and leishmaniasis, twelve new 1,4-di-N-oxide quinoxaline derivatives were synthesized and evaluated for their in vitro antimalarial and antileishmanial activity against Plasmodium falciparum FCR-3 strain, Leishmania infantum and Leishmania amazonensis. Their toxicity against VERO cells (normal monkey kidney cells) was also assessed. The results obtained indicate that a cyclopentyl derivative had the best antiplasmodial activity (2.9 µM), while a cyclohexyl derivative (2.5 µM) showed the best activity against L. amazonensis, and a 3-chloropropyl derivative (0.7 µM) showed the best results against L. infantum. All these compounds also have a Cl substituent in the R7 position
Fichier principal
Vignette du fichier
Barea_2013.pdf (192.41 Ko) Télécharger le fichier
Origine Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-03531079 , version 1 (18-01-2022)

Licence

Identifiants

Citer

Carlos Barea, Adriana Pabón, Silvia Pérez-Silanes, Silvia Galiano, German Gonzalez, et al.. New Amide Derivatives of Quinoxaline 1,4-di-N-Oxide with Leishmanicidal and Antiplasmodial Activities. Molecules, 2013, 18 (4), pp.4718-4727. ⟨10.3390/molecules18044718⟩. ⟨hal-03531079⟩
14 Consultations
24 Téléchargements

Altmetric

Partager

More