Metabolic and cardiovascular adaptations to an 8-week lifestyle weight loss intervention in younger and older obese men - Université Toulouse III - Paul Sabatier - Toulouse INP Accéder directement au contenu
Article Dans Une Revue AJP - Endocrinology and Metabolism Année : 2021

Metabolic and cardiovascular adaptations to an 8-week lifestyle weight loss intervention in younger and older obese men

Résumé

The number of older obese adults is increasing worldwide. Whether obese adults show similar health benefits in response to lifestyle interventions at different ages is unknown. The study enrolled 25 obese men (BMI 31-39 kg/m2) in two arms according to age (30-40 and 60-70 years old). Participants underwent an 8-week intervention with moderate calorie restriction (~20% below individual energy requirements) and supervised endurance training resulting in ~5% weight loss. Body composition was measured using dual energy X-Ray absorptiometry. Insulin sensitivity was assessed during a hypersinsulinemic euglycemic clamp. Cardiometabolic profile was derived from blood parameters. Subcutaneous fat and vastus lateralis muscle biopsies were used for ex vivo analyses. Two-way repeated-measure ANOVA and linear mixed models were used to evaluate the response to lifestyle intervention and comparison between the two groups. Fat mass was decreased and bone mass was preserved in the two groups after intervention. Muscle mass decreased significantly in older obese men. Cardiovascular risk (Framingham risk score, plasma triglyceride and cholesterol) and insulin sensitivity were greatly improved to a similar extent in the two age groups after intervention. Changes in adipose tissue and skeletal muscle transcriptomes were marginal. Analysis of the differential response to the lifestyle intervention showed tenuous differences between age groups. These data suggest that lifestyle intervention combining calorie restriction and exercise shows similar beneficial effects on cardiometabolic risk and insulin sensitivity in younger and older obese men. However, attention must be paid to potential loss of muscle mass in response to weight loss in older obese men.
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Dates et versions

hal-03320052 , version 1 (13-08-2021)

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Citer

Julie Vion, Veronika Sramkova, Emilie Montastier, Marie-Adeline Marquès, Sylvie Caspar-Bauguil, et al.. Metabolic and cardiovascular adaptations to an 8-week lifestyle weight loss intervention in younger and older obese men. AJP - Endocrinology and Metabolism, In press, 321 (3), pp.E325-E337. ⟨10.1152/ajpendo.00109.2021⟩. ⟨hal-03320052⟩
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