Baseline and post-treatment hepatitis C NS5A resistance in relapsed patients from a multicentric real-life cohort - Université Toulouse III - Paul Sabatier - Toulouse INP
Article Dans Une Revue Antiviral Therapy Année : 2018

Baseline and post-treatment hepatitis C NS5A resistance in relapsed patients from a multicentric real-life cohort

Fabien Zoulim
Vincent Leroy
  • Fonction : Auteur
Denis Ouzan

Résumé

Background: Recent data have suggested that failure to achieve sustained virological response with direct-acting antiviral therapy is usually due to relapse and is primarily associated with the emergence of resistance-associated substitutions. The aim of this study was to investigate the prevalence and characterization of non-structural-5A resistance-associated substitutions in patients infected with HCV genotypes 1, 3 and 4 treated by direct-acting antiviral therapy, including anti-non-structural-5A, and to characterize the pre-existing resistance-associated substitutions in subjects treated with anti-non-structural-5A inhibitors. Methods: From January 2014 to March 2016, 2,995 patients infected with HCV genotypes 1, 3 and 4 were exposed to non-structural-5A inhibitors. Sequencing results at the time of virological failure were available for 61 patients; sequencing at baseline was available for 35 of these patients. Results: Among the 35 patients with sequencing results available at baseline, 15 had no resistance-associated substitution, 16 had only one resistance-associated substitution, and 4 had more than one resistance-associated substitution. Resistance-associated substitutions were harbored in 57% of the sequences in the non-structural-5A region. Among the 61 patients sequenced at virological failure, 50 (82%) patients presented at least one resistance-associated substitutions inducing a high level of resistance to non-structural-5A inhibitors (>10-fold resistance). Conclusions: This pooled analysis suggests that non-structural-5A resistance-associated substitutions screening should be recommended when considering retreatment with a non-structural-5A inhibitor regimen in patients who have previously experienced failed non-structural-5A treatment.
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Dates et versions

hal-03120487 , version 1 (25-01-2021)

Identifiants

Citer

Philippe Halfon, Caroline Scholtes, Jacques Izopet, Sylvie Larrat, Pascale Trimoulet, et al.. Baseline and post-treatment hepatitis C NS5A resistance in relapsed patients from a multicentric real-life cohort. Antiviral Therapy, 2018, 23 (4), pp.307-314. ⟨10.3851/IMP3184⟩. ⟨hal-03120487⟩

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